{"id":270,"date":"2020-10-29T16:30:00","date_gmt":"2020-10-29T14:30:00","guid":{"rendered":"https:\/\/biophysics.pmfst.unist.hr\/?p=270"},"modified":"2023-10-11T13:27:12","modified_gmt":"2023-10-11T11:27:12","slug":"javna-online-obrana-doktorskog-rada-matee-kanunnikau","status":"publish","type":"post","link":"https:\/\/biophysics.pmfst.unist.hr\/en\/javna-online-obrana-doktorskog-rada-matee-kanunnikau\/","title":{"rendered":"Javna online obrana doktorskog rada Matee Kanunnikau"},"content":{"rendered":"\n

OBAVIJEST<\/strong><\/p>\n\n\n\n

Javna online<\/em> obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA<\/p>\n\n\n\n

MATEE KANUNNIKAU<\/strong><\/h2>\n\n\n\n

pod naslovom<\/p>\n\n\n\n

\u201cModifikacija statusa proteostaze: uloga komunikacije izme\u0111u stani\u010dnih organela\u201d<\/strong><\/h2>\n\n\n\n

odr\u017eat \u0107e se u petak, 6. studenog 2020., u 15:00<\/strong>, pred \u010dlanovima Stru\u010dnog povjerenstva:<\/p>\n\n\n\n

    \n
  1. prof. dr. sc. Katarina Vukojevi\u0107<\/strong> (Medicinski fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 predsjednica,<\/li>\n\n\n\n
  2. prof. dr. sc. Irena Drmi\u0107 Hofman<\/strong> (Medicinski fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 \u010dlanica,<\/li>\n\n\n\n
  3. prof. dr. sc. Biljana Balen<\/strong> (Prirodoslovno-matemati\u010dki fakultet Sveu\u010dili\u0161ta u Zagrebu) \u2013 \u010dlanica.<\/li>\n<\/ol>\n\n\n\n

    Mentorica: dr. sc. Anita Kri\u0161ko<\/strong> (Mediteranski institut za istra\u017eivanje \u017eivota u Splitu i Medicinski fakultet Sveu\u010dili\u0161ta u G\u00f6ttingenu).<\/p>\n\n\n\n

    Naslov:
    Modifikacija statusa proteostaze: uloga komunikacije izme\u0111u stani\u010dnih organela<\/strong><\/p>\n\n\n\n

    Sa\u017eetak:<\/h3>\n\n\n\n

    Kontinuirana izlo\u017eenost osciliraju\u0107im uvjetima, unutarnjim i vanjskim, predstavljaju izazov za o\u010duvanjem uravnote\u017eenog proteoma \u0161to regulirano proteostatskom mre\u017eom. Najistaknutiji segment navedene mre\u017ee su molekularni \u0161aperoni koji uslijed svoje dinami\u010dnosti i raznolikosti omogu\u0107avaju stabilizaciju proteina. Separacijom stanice u zasebne odjeljke ste\u010deni su pripadaju\u0107i \u0161aperoni karakteristi\u010dni za svaki organel. Kompartmentalizacijom eukariotske stanice je omogu\u0107eno uspostavljanje te o\u010duvanje proteostaze u izdvojenim odjeljcima. Ova \u010dinjenica je bila poticaj za prou\u010davanje utjecaja pobolj\u0161anja i pogor\u0161anja proteostaze u izdvojenim stani\u010dnim odjeljcima na stanicu. Obuhvatnim i detaljnim eksperimentima je pokazano da modifikacija proteostaze, bilo delecijom ili overekspresijom pojedinih \u0161aperona, kulminira produljenjem replikativnog \u017eivotnog vijeka, neovisno o ishodi\u0161tu same modifikacije. Pretpostavka ovog istra\u017eivanja je da je ovaj cijelostani\u010dni odaziv proveden kroz raspoznavanje i korespondenciju konformacijske vrsno\u0107e proteoma u zasebnim stani\u010dnim odjeljcima, odaziv formuliran u ovoj studiji kao odaziv na stres kroz organele<\/em> (CORE).<\/p>\n\n\n\n

    Title:
    Modifying the proteostatis status: the role of cross-organelle communication<\/strong><\/p>\n\n\n\n

    Abstract:<\/h3>\n\n\n\n

    Perpetual exposure to fluctuating intrinsic and environmental conditions constitute a challenge for maintaining a stable proteome, and this predicament is surmounted by an intricate system of precisely controlled mechanisms that constitute proteostasis. Proteostasis, or protein homeostasis, is orchestrated by an elaborate interlock of signaling pathways collectively known as the proteostasis network, with molecular chaperones constituting its most prominent component. The compartmentalized eukaryotic cell has ascertained organelle-specific chaperones to surmount challenges to proteostasis, and this idiosyncrasy was resolved to be used to study cell-wide effect upon proteostasis modifications in distinct cellular compartments. This study revealed an elaborate cross-organelle communication networking system upon compartmentalized improvement of proteostasis, induced by chaperone enrichment, as well as mild deterioration of proteostasis, induced by chaperone deletions. Comprehensive and detailed experiments confirmed that the improvement of proteostasis, as well as its mild deterioration initiates a cell-wide response which, ultimately, entails replicative lifespan extension, irrespective of the origin of alteration. This research postulates that this cell-wide response is orchestrated by sensing and mediating the protein folding quality status of the proteome in distinct cellular compartments, a response termed here cross-organelle stress response<\/em> (CORE).<\/p>\n\n\n\n

    Pozivaju se svi zainteresirani da prisustvuju online obrani putem Jitsi Meet<\/em> sustava za koji je potrebno imati instalirani web preglednik Chrome<\/em> ili Firefox<\/em>.<\/p>\n\n\n\n

    Javnoj obrani doktorskog rada pristupa se putem linka:<\/p>\n\n\n\n

    https:\/\/meet.jit.si\/Obrana_doktorskog_rada_Matea_Kanunnikau<\/a><\/p>\n\n\n\n

    \"upute<\/figure>\n\n\n\n

    ili na mre\u017enoj stranici https:\/\/meet.jit.si<\/a> upisati naziv sastanka:<\/p>\n\n\n\n

    Obrana_doktorskog_rada_Matea_Kanunnikau i stisnuti GO.<\/p>\n\n\n\n

    \"upute<\/figure>\n\n\n\n

    Priklju\u010denje javnoj obrani doktorskog rada bit \u0107e mogu\u0107e pola sata prije po\u010detka obrane:<\/p>\n\n\n\n

    6. studenog 2020. od 14:30 h.<\/p>\n\n\n\n

    Obavijest \u2013 javna online obrana doktorskog rada Matee Kanunnikau<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    OBAVIJEST Javna online obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA MATEE KANUNNIKAU pod naslovom \u201cModifikacija statusa proteostaze: uloga komunikacije izme\u0111u stani\u010dnih organela\u201d odr\u017eat \u0107e se u petak, 6. studenog 2020., u 15:00, pred \u010dlanovima Stru\u010dnog povjerenstva: Mentorica: dr. sc. Anita Kri\u0161ko (Mediteranski institut za istra\u017eivanje \u017eivota u Splitu i Medicinski fakultet Sveu\u010dili\u0161ta u G\u00f6ttingenu).<\/p>\n","protected":false},"author":1,"featured_media":701,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,16],"tags":[],"class_list":["post-270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-defences-of-doctoral-theses","category-news-and-updates"],"acf":[],"_links":{"self":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/comments?post=270"}],"version-history":[{"count":3,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/270\/revisions"}],"predecessor-version":[{"id":717,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/270\/revisions\/717"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media\/701"}],"wp:attachment":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media?parent=270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/categories?post=270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/tags?post=270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}