{"id":313,"date":"2022-07-15T16:51:00","date_gmt":"2022-07-15T14:51:00","guid":{"rendered":"https:\/\/biophysics.pmfst.unist.hr\/?p=313"},"modified":"2023-10-11T13:26:31","modified_gmt":"2023-10-11T11:26:31","slug":"javna-obrana-doktorskog-rada-martine-peric-bakulic","status":"publish","type":"post","link":"https:\/\/biophysics.pmfst.unist.hr\/en\/javna-obrana-doktorskog-rada-martine-peric-bakulic\/","title":{"rendered":"Javna obrana doktorskog rada Martine Peri\u0107 Bakuli\u0107"},"content":{"rendered":"\n<p><strong>OBAVIJEST<\/strong><\/p>\n\n\n\n<p>Javna obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>MARTINE PERI\u0106 BAKULI\u0106, mag. phys.<\/strong><\/h2>\n\n\n\n<p>pod naslovom<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u201cDizajn novih nanostrukturnih materijala za primjenu u biosenzorici;<\/strong> <strong>teorijsko istra\u017eivanje opti\u010dkih svojstava bio-nano hibrida plemenitih metala\u201d<\/strong><\/h2>\n\n\n\n<p>odr\u017eat \u0107e se u <strong>petak, 22. srpnja 2022., u 11:00 sati<\/strong> na Prirodoslovno-matemati\u010dkom fakultetu u Splitu (amfiteatar A-01), pred \u010dlanovima Stru\u010dnog povjerenstva:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>prof. dr. sc. Ante Bilu\u0161i\u0107<\/strong> (Prirodoslovno-matemati\u010dki fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 predsjednik,<\/li>\n\n\n\n<li><strong>prof. dr. sc. Katarina Vukojevi\u0107<\/strong> (Medicinski fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 \u010dlanica,<\/li>\n\n\n\n<li><strong>doc. dr. sc. Viljemka Bu\u010devi\u0107-Popovi\u0107<\/strong> (Prirodoslovno-matemati\u010dki fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 \u010dlanica,<\/li>\n\n\n\n<li><strong>izv. prof. dr. sc. Larisa Zorani\u0107<\/strong> (Prirodoslovno-matemati\u010dki fakultet Sveu\u010dili\u0161ta u Splitu) \u2013 zamjenska \u010dlanica.<\/li>\n<\/ol>\n\n\n\n<p><strong>Mentorica i komentor<\/strong>: <strong>prof. dr. dr. h. c. Vlasta Bona\u010di\u0107 Kouteck\u00fd<\/strong> (Centar izvrsnosti za znanost i tehnologiju \u2013 integracija Mediteranske regije (STIM) pri Interdisciplinarnom centru za naprednu znanost i tehnologiju (ICAST)) i <strong>prof. dr. sc. Mile D\u017eelalija<\/strong> (Prirodoslovno-matemati\u010dki fakultet Sveu\u010dili\u0161ta u Splitu).<\/p>\n\n\n\n<p><strong>Pozivaju se svi zainteresirani da prisustvuju obrani doktorskog rada.<\/strong><\/p>\n\n\n\n<p>Naslov:<br><strong>Dizajn novih nanostrukturnih materijala za primjenu u biosenzorici; teorijsko istra\u017eivanje opti\u010dkih svojstava bio-nano hibrida plemenitih metala<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sa\u017eetak:<\/h3>\n\n\n\n<p>Te\u017ei\u0161te ovog doktorskog rada po\u010diva na linearnim i nelinearnim opti\u010dkim svojstvima nanoklastera plemenitih metala koji pripadaju neskaliraju\u0107im sustavima (~2 nm). Mogu biti ugra\u0111eni u biolo\u0161ki okoli\u0161 kao bio-nano hibridi ili za\u0161ti\u0107eni biomolekulama kao ligandirani nanoklasteri. U usporedbi sa standardnim tehnikama bio-oslikavanja u medicinskoj dijagnostici (organske boje i kvantne to\u010dke) bolja osjetljivost mo\u017ee se posti\u0107i kombinacijom dvofotonske spektroskopije i bio-nano sustava plemenitih metala. Istra\u017eivanje predstavljeno u ovom doktorskom radu temelji se na metodama ra\u010dunalne kvantne kemije. Kombinacija QM\/MM metode s teorijom funkcionala gusto\u0107e (DFT) i njezinom vremenski ovisnom ina\u010dicom (TD-DFT) omogu\u0107uje odre\u0111ivanje strukturnih i opti\u010dkih svojstava za bio-nano hibride (trimer srebra interkaliran u DNK i supramolekularni sklopovi zlata i cisteina dopirani s jednim atomom srebra) te ligandirane nanoklastere (Au<sub>10<\/sub>SG<sub>10<\/sub>, Au<sub>12<\/sub>Zwitterions<sub>4<\/sub>, i Au<sub>15<\/sub>SG<sub>13<\/sub>). Istra\u017eivanje u ovom doktorskom radu pokazalo je da njihova jedinstvena opti\u010dka svojstva (intezivna fluorescencija kod bio-nano hibrida te zna\u010dajan kapacitet u bio-ozna\u010davanju kod ligandiranih nanoklastera) imaju potencijal za primjenu u bio-oslikavanju i medicinskoj dijagnostici. O\u010dekuje se da \u0107e novi pravci teorijskog istra\u017eivanja voditi istra\u017eivanja prema biosenzorici visoke osjetljivosti. Teorijski rezultati \u0107e se usporediti s eksperimentalnim rezultatima dobivenim od strane eksperimentalnih stru\u010dnjaka<\/p>\n\n\n\n<p>Title:<br><strong>Design of new nanostructured materials for application in biosensorics; theoretical study of optical properties of noble metal bio-nano hybrids<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract:<\/h3>\n\n\n\n<p><\/p>\n\n\n\n<p>The focus of this doctoral thesis is to address the linear andnonlinear optical properties of noble metal nanoclusters (NCs) belonging to the nonscalable regime ( 2nm). They can be embedded in the biological environment as bio-nano hybrids or protected with biomolecules as liganded NCs. Compared to standard bioimaging techniques (organic dyes and quantum dots) better sensitivity can be reached with the combination of two-photon spectroscopy and noble metal bio-nano systems. The research presented in this doctoral thesis is based on an investigation by computational chemistry methods. The combination of the QM\/MM method with Density Functional Theory (DFT) and its time-dependent version (TD-DFT) allows the determination of structural and optical properties for bio-nano hybrids (silver trimer intercalated in DNA and silver doped gold-cysteine supramolecular assemblies) and ligated NCs (Au<sub>10<\/sub>SG<sub>10<\/sub>, Au<sub>12<\/sub>Zwitterions<sub>4<\/sub>, and Au<sub>15<\/sub>SG<sub>13<\/sub>). Research in this doctoral thesis demonstrated that their unique optical properties (huge fluorescence for investigated bio-nano hybrids and bio-labeling capacity of liganded NCs) have the potential for applications in bioimaging and medical diagnostics. New routes of theoretical exploration are expected to lead the research towards biosensorics of superior sensitivity. Theoretical results will be compared with experimental results obtained by expert collaborato<\/p>\n\n\n\n<p><a href=\"https:\/\/biophysics.pmfst.unist.hr\/wp-content\/uploads\/2023\/10\/Obavijest_o_javnoj_obrani_doktorskog_rada_MPericBakulic.pdf\" data-type=\"link\" data-id=\"https:\/\/biophysics.pmfst.unist.hr\/wp-content\/uploads\/2023\/10\/Obavijest_o_javnoj_obrani_doktorskog_rada_MPericBakulic.pdf\">Obavijest \u2013 javna obrana doktorskog rada Martine Peri\u0107 Bakuli\u0107<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>OBAVIJEST Javna obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA MARTINE PERI\u0106 BAKULI\u0106, mag. phys. pod naslovom \u201cDizajn novih nanostrukturnih materijala za primjenu u biosenzorici; teorijsko istra\u017eivanje opti\u010dkih svojstava bio-nano hibrida plemenitih metala\u201d odr\u017eat \u0107e se u petak, 22. srpnja 2022., u 11:00 sati na Prirodoslovno-matemati\u010dkom fakultetu u Splitu (amfiteatar A-01), pred \u010dlanovima Stru\u010dnog povjerenstva:<\/p>\n","protected":false},"author":1,"featured_media":701,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,16],"tags":[],"class_list":["post-313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-defences-of-doctoral-theses","category-news-and-updates"],"acf":[],"_links":{"self":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/comments?post=313"}],"version-history":[{"count":2,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/313\/revisions"}],"predecessor-version":[{"id":715,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/313\/revisions\/715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media\/701"}],"wp:attachment":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media?parent=313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/categories?post=313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/tags?post=313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}