{"id":429,"date":"2020-03-18T14:47:00","date_gmt":"2020-03-18T12:47:00","guid":{"rendered":"https:\/\/biophysics.pmfst.unist.hr\/?p=429"},"modified":"2023-10-11T13:29:20","modified_gmt":"2023-10-11T11:29:20","slug":"javna-obrana-doktorskog-rada-ivane-gunjace","status":"publish","type":"post","link":"https:\/\/biophysics.pmfst.unist.hr\/en\/javna-obrana-doktorskog-rada-ivane-gunjace\/","title":{"rendered":"Javna obrana doktorskog rada Ivane Gunja\u010de"},"content":{"rendered":"\n

OBAVIJEST<\/strong><\/p>\n\n\n\n

Javna on-line obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA<\/p>\n\n\n\n

IVANE GUNJA\u010cE<\/strong><\/h2>\n\n\n\n

pod naslovom<\/p>\n\n\n\n

\u201cOtkrivanje geneti\u010dkih \u010dimbenika povezanih s ukupnom razinom hormona \u0161titne \u017elijezde u serumu\u201d<\/strong><\/h2>\n\n\n\n

odr\u017eat \u0107e se u utorak, 24. o\u017eujka 2020., u 14:00 sati<\/strong>, pred \u010dlanovima Stru\u010dnog povjerenstva:<\/p>\n\n\n\n

    \n
  1. prof. dr. sc. Irena Drmi\u0107 Hofman (Medicinski fakultet, Split) \u2013 predsjednica<\/li>\n\n\n\n
  2. prof. dr. sc. Jasna Puizina (Prirodoslovno-matemati\u010dki fakultet, Split) \u2013 \u010dlanica<\/li>\n\n\n\n
  3. doc. dr. sc. Matilda \u0160prung (Prirodoslovno-matemati\u010dki fakultet, Split) \u2013 \u010dlanica<\/li>\n<\/ol>\n\n\n\n

    Mentori<\/strong>: izv. prof. dr. sc. Maja Barbali\u0107 (Medicinski fakultet, Split) i
    izv. prof. dr. sc. Marija Ragu\u017e (Medicinski fakultet, Split).<\/p>\n\n\n\n

    Pozivaju se svi zainteresirani da prisustvuju on-line obrani putem linka:<\/p>\n\n\n\n

    https:\/\/teams.microsoft.com\/l\/meetup-join\/19%3ameeting_NTZhMjI5NWYtNWZhZC00ODAxLTliMTktZWYyNzNjNTYxN2Iy%40thread.v2\/0?context=%7b%22Tid%22%3a%22295965bf-02be-42d1-a3a6-f4ed25839e28%22%2c%22Oid%22%3a%2259a41207-36c5-4405-be79-02c5d2f8cbd1%22%7d<\/a><\/p>\n\n\n\n

    a za priklju\u010denje molim Vas slijediti upute:<\/p>\n\n\n\n

    \"upute<\/figure>\n\n\n\n

    Kliknuti na \u201cjoin on the web instead<\/strong>\u201d pa:<\/p>\n\n\n\n

    \"upute<\/figure>\n\n\n\n

    Stisnuti \u201dallow<\/strong>\u201d<\/p>\n\n\n\n

    \"upute<\/figure>\n\n\n\n

    Upisati ime, i kliknuti \u201cjoin now<\/strong>\u201c, i pri\u010dekati dopu\u0161tenje.<\/p>\n\n\n\n

    Naslov:
    Otkrivanje geneti\u010dkih \u010dimbenika povezanih s ukupnom razinom hormona \u0161titne \u017elijezde u serumu<\/strong><\/p>\n\n\n\n

    Sa\u017eetak:<\/h3>\n\n\n\n

    Hormoni \u0161titnja\u010de, tiroksin (T4<\/sub>) i trijodtironin (T3<\/sub>), su neophodni za normalan rast, razvoj i metabolizam svake stanice u tijelu. Serumski parametri hormona \u0161titnja\u010de pokazuju zna\u010dajnu raznolikost izme\u0111u zdravih pojedinaca koja je, pored okoli\u0161nih \u010dimbenika, u znatnoj mjeri odre\u0111ena i geneti\u010dkim \u010dimbenicima. S ciljem otkrivanja geneti\u010dkih \u010dimbenika koji utje\u010du na koncentracije ukupnih hormona \u0161titnja\u010de, provedena je prva meta-analiza cjelogenomskih analiza povezanosti za ukupnu koncentraciju hormona T4 <\/sub>na 1121 ispitaniku s podru\u010dja grada Splita i otoka Kor\u010dule. Provedene su i cjelogenomske analize povezanosti za ukupnu koncentraciju hormona T3<\/sub> i omjer T3<\/sub>\/T4<\/sub> za ispitanike s podru\u010dja grada Splita. Cjelogenomskim analizama povezanosti identificirane su genske varijante povezane s ukupnom koncentracijom hormona T4 <\/sub>i omjerom T3<\/sub>\/T4<\/sub>. Navedene analize nadopunjuju postoje\u0107e znanje o geneti\u010dkoj pozadini funkcije \u0161titne \u017elijezde te doprinose boljem razumijevanju biolo\u0161kih putova povezanih s funkcijom \u0161titnja\u010de.<\/p>\n\n\n\n

    Title:
    Identification of genetic factors associated with total serum levels of thyroid hormones<\/strong><\/p>\n\n\n\n

    Abstract:<\/h3>\n\n\n\n

    Thyroid hormones (TH), thyroxine (T4<\/sub>) and triiodothyronine (T3<\/sub>) are essential for the normal growth, development, and metabolism of every cell in the body. In healthy individuals, serum thyroid parameters show significant interindividual variability mainly determined by genetic factors, in addition to environmental factors. To detect genetic variants associated with total THs levels, the first genome-wide meta-analysis of total T4<\/sub> levels was carried out in 1121 individuals from the city of Split and the island of Kor\u010dula. The genome-wide association analyses of total T3<\/sub> levels and T3<\/sub>\/T4<\/sub> ratio were conducted in the individuals from the city of Split. The most significant results of the genome-wide association analyses are the identification of the genetic variants with the total T4<\/sub> levels, and T3<\/sub>\/T4<\/sub> ratio. This study improves the current knowledge of the genetic factors regulating TH levels and contributes to a better understanding of the biological pathways associated with thyroid function.<\/p>\n\n\n\n

    Obavijest \u2013 javna on-line obrana doktorskog rada Ivane Gunja\u010de<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    OBAVIJEST Javna on-line obrana doktorskog rada studentice poslijediplomskog sveu\u010dili\u0161nog studija BIOFIZIKA IVANE GUNJA\u010cE pod naslovom \u201cOtkrivanje geneti\u010dkih \u010dimbenika povezanih s ukupnom razinom hormona \u0161titne \u017elijezde u serumu\u201d odr\u017eat \u0107e se u utorak, 24. o\u017eujka 2020., u 14:00 sati, pred \u010dlanovima Stru\u010dnog povjerenstva: Mentori: izv. prof. dr. sc. Maja Barbali\u0107 (Medicinski fakultet, Split) iizv. prof. dr.<\/p>\n","protected":false},"author":1,"featured_media":701,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,16],"tags":[],"class_list":["post-429","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-defences-of-doctoral-theses","category-news-and-updates"],"acf":[],"_links":{"self":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/comments?post=429"}],"version-history":[{"count":3,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/429\/revisions"}],"predecessor-version":[{"id":722,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/posts\/429\/revisions\/722"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media\/701"}],"wp:attachment":[{"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/media?parent=429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/categories?post=429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biophysics.pmfst.unist.hr\/en\/wp-json\/wp\/v2\/tags?post=429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}